Задайте четыре типа вопросов к предложению: the manner in which theoretical principles are formulated and used in applications varies greatly from one science to another.

 

The manner in which theoretical principles are formulated and used in applications varies greatly from one science to another, doesn’t it?

Does the manner in which theoretical principles are formulated and used in applications vary greatly from one science to another?
 What varies greatly from one science to another?
 Does the manner in which theoretical principles are formulated and used in applications vary greatly or slightly from one science to another?